NF-κB signalling involves actions of five family member protein subunits/protein subunit complexes, including NF-κB1, NF-κB2, RelA (p65), RelB and c-Rel, controlling DNA transcription and subsequent expression of pro-inflammatory cytokines (such as TNF) to play a pivotal role in regulating immune response to infection [54,55]. Here, RELB is linked to infection.