Macrophage function and clearance of bacterial infection is not altered by the absence of Nfκb1 p50 subunit in vivo [53]; however, here we have shown that exemplar CD mucosal E. coli strains LF82 and HM605 cannot survive within Nfκb1-/- BMDMs, suggesting that inhibiting classical NF-κB pathway signalling specifically within macrophages could be therapeutically useful [54]. This evidence concerns the gene NFKB1 and bacterial infectious disease.