Soluble NKG2DLs (sNKG2DLs), such as MICA that is shed from the surface of prostate cancer, ovarian cancer, and leukemia cells, bind to NKG2D on NK cells, this blocks the recognition of NKG2DLs expressed in cancer, resulting in tumor immune escape from NK cell surveillance [4,42,43]. Here, MICA is linked to neoplasm.