Down regulation of WNT signaling has been described specifically in chondrodystrophic dog degenerate nucleus pulposus [27], and a downregulating frameshift variant in the WNT pathway gene Dishevelled 2 (DVL2) was also recently identified and associated with screw tail and brachycephaly in Bulldogs, French Bulldogs, and Boston terriers [29]. Here, DVL2 is linked to Brachycephaly.