To this end, peripheral blood mononuclear cells (PBMCs) of healthy donors containing NK cells as effector cells were cultured with the CRC cell lines Caco-2, HCT-116, and HT-29 with their high, intermediate, and low CD133 antigen densities, respectively, in the presence or absence of 293C3-SDIE or isotype control. Here, PROM1 is linked to colorectal carcinoma.