Therefore, regardless of the upstream signals, the aforementioned findings and our results suggest that TGF-β1, Src, and fibronectin could work in concert to shape a mesenchymal-like morphology and predispose RCC cells to cell growth and migration, involving induction of cyclin D1, vimentin, and other unidentified molecules. This evidence concerns the gene TGFB1 and renal cell carcinoma.