COL1A1 and breast carcinoma: It is consistent with recent findings showing that COL1A1, activated by multiple signaling pathways in a myocardin-related transcription factor A (MRTFA)-mediated manner, is highly expressed in human breast cancer [29], additionally COL1A1 and COL1A2 mRNA levels are significantly upregulated in gastric cancer tissues compared to normal tissues, and lower COL1A1 and COL1A2 expression levels are strongly associated with better overall survival in patients with gastric cancer [30].