COL1A1 and hepatocellular carcinoma: Since enhanced migration and invasion are characteristic of metastatic or late-stage disease [22], we investigated the probable role of COL1A1 in the enhanced metastatic phenotype of HCC cells using siRNA-mediated transient loss of COL1A1 function in human HBV+ grade IV/V pleomorphic HCC SNU-387 cells, and HBV+ grade II–IV/V HCC SNU-475 cells.