This markedly elevated COL1A1 mRNA expression profile was replicated in GSE3500 (p = 0.01), GSE14520 (p = 4.26 × 10−4) and GSE6764 (p = 1.68 × 10−6) HCC samples, compared to their normal counterparts (Figure 2B). Here, COL1A1 is linked to hepatocellular carcinoma.