COL1A1 and hepatocellular carcinoma: Furthermore, for translational relevance, using the functional characterization and druggability studies of COL1A1, associated co-expressed MHC class I and II proteins, cell survival genes and HCC stemness markers, we demonstrated that COL1A1is a highly druggable oncogene that is overexpressed in patients with HCC, as found in the SAMSUNG HCC (n = 6,619), Asian Cancer Research Group (ACRG) HCC (n = 88) and TGCA LIHC (n = 373) cohorts (Figure 5D).