VIM and colorectal carcinoma: In fact, additional corroboration of our findings is found in the work of Toiyama et al. [35] showing that while Slug and vimentin are highly expressed in higher tumor (T) stage, lymph-node involvement, hepatic metastasis and advanced TMN stage, siRNA-silencing of Slug in CRC cells induced reduction in cell proliferation, suppressed EMT, and attenuated the invasion and migration in CRC cells.