However, the expression of COL1A1 and COL1A2 in normal epithelium, premalignant and tumor lesions of the stomach is rarely mentioned, and while type I collagen has been associated with hepatic fibrosis [20], there is a dearth of information on the clinical significance of COL1A1 in patients with HCC, thus, the present study investigate the role of COL1A1 in HCC. This evidence concerns the gene COL1A2 and neoplasm.