GLP1R and hyperuricemia: There are well-recognized indirect effects of high fructose intake promoting systemic factors that contribute to WAT expansion (Figure 1), including fructose-increased caloric intake mediated via leptin resistance [7] and the antagonism of glucagon-like peptide-1 receptor (GLP-1R) action in the brain [34], as well as hyperuricemia [1] and visceral WAT inflammation [35].