Indeed, proteins involved in DNA repair were among the most highly enriched, many of which have already been reported to participate in CFS repair, including the MRN complex (MRE11, RAD50 and NBN), BRCA1 and its constitutive partner BARD1, and the BTR complex (BLM, TOP3A and RMI proteins) (16,40–43). The gene discussed is TOP3A; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.