Our previous result has shown that ectopic expression of the constant active form of cyclin D1 (T286A mutant) [33] caused a significant decrease of the NTCP promoter activity in the HCC cell lines SMMC7721 containing wild-type p53 and Huh-7 bearing a p53-Y220C mutation [20]. The gene discussed is CCND1; the disease is hepatocellular carcinoma.