To determine whether ERK activation is involved in the function of Sema7A in epilepsy, we detected the levels of IL‐6 and TNF‐α in the presence of U0126 after injecting the lentiviral vector Sema7A (Figure 9A), and the phosphorylation levels of ERK1 and ERK2 were significantly inhibited in the U0126‐treated group compared with those in the DMSO‐treated group after PTZ kindling (P < 0.05; Figure 9B). This evidence concerns the gene MAPK3 and epilepsy.