Upregulation of EZH2, an integral part of the PRC2 complex, leads to the transcriptional repression of differentiation genes and maintains stem-like cell properties.42 Recent studies have established the PRC2 complex has high-binding affinity for methylated cytosines,43 making a direct connection between histone and DNA epigenetics.44 In addition, EZH2 is integral to the biology of HR neuroblastoma and considered a potential therapeutic target in the disease.45 Here, EZH2 is linked to neuroblastoma.