HRAS and neuroblastoma: Neuronal differentiation is a hallmark of LR tumors,38 and studies indicate HRAS expression drives this phenotype.39 Pathway analysis also suggested a role for the PRC1 complex, which promotes gene silencing by monoubiquitinating histone 2A.40 Additional efforts are needed to confirm our findings, which could provide additional evidence for targeting BMI1 in neuroblastoma.41