CD274 and neoplasm: Based on preclinical data of upregulation of PD-L1 expression on tumor cells after chemotherapy and radiotherapy [85], in the double-blind phase III PACIFIC trial, durvalumab up to 1 year improved median PFS over placebo in patients with stage III A/B after concomitant definitive chemoradiation (16.8 versus 5.6 months, HR 0.52, 95%CI 0.42-0.65, p<0.001), with an acceptable toxicity profile.