To explore the role of survivin in hypoxia-induced MDR in human laryngeal neoplasm, AMC-HN-8 and Hep-2 cells were firstly transfected with either a double-strand siRNA oligonucleotide that targeted survivin (survivin-siRNA) or scrambled siRNA for 24 hours before another 24-hour incubation in hypoxia. Here, BIRC5 is linked to laryngeal neoplasm.