In the present study, YAP1 overexpression inhibited the phosphorylation of AKT and reduced the effect of miR-21 on renal cell apoptosis and migration, supporting the hypothesis that Eupatilin inhibits the expression of miR-21 in renal cancer cells and that miR-21 regulates apoptosis and migration in RCC by targeting YAP1. Here, YAP1 is linked to renal carcinoma.