MARK4 and hepatocellular carcinoma: Our recent work indicates the depletion of microRNA-122 (miR-122, a dominant microRNA in normal liver cells) (Bandiera et al., 2015) upregulates septin-9 expression, facilitates the phosphorylation of microtubule-associated proteins 4 (MAP4) by microtubule affinity-regulating kinase (MARK4), causes detachment of the MAP4 from the microtubule, increasing microtubule dynamics and therefore conferring paclitaxel resistance in HCC (Sun et al., 2016).