Circ-TTBK2 regulated the miR-217/HNF1b/Derlin-1 pathway to promote the progression of glioma (27); and circ-SHKBP1 regulated the angiogenesis of U87 glioma-exposed endothelial cells through miR-544a/FOXP1 and miR-379/FOXP2 pathways (28). This evidence concerns the gene TTBK2 and central nervous system cancer.