Compared with HCC patients without HBV infection, HCC patients with HBV infection were 10 years younger and had higher proportions of positive AFP (≥20 ng/ml), positive CA19-9 (≥37 U/ml), the presence of liver cirrhosis, high direct bilirubin (>7 μmol/L), advanced BCLC stage, and the presence of MVI and lower proportions of NLR (>3.3) and PLR (>117; Table 1). The gene discussed is AFP; the disease is hepatocellular carcinoma.