Upregulation of HIF-1α
transcription factor(25) • increases PD-L1 expression on tumor cells and myeloid-derived suppressor cells (MDSCs) (26) • induces VEGF-A production from tumor cells which recruits Tregs and MDSC and suppresses DC maturation (27) • increases shedding of NKG2D ligand MICA from tumor cells reducing NK cell killing (28). This evidence concerns the gene MICA and neoplasm.