Induction of senescence-associated secretory phenotype (SASP) in cancer-associated fibroblasts (CAFs) • drives chronic inflammation and protumorogenic TME (39) • activation of insulin-like growth factor-1/receptor (IGF1/IGF-1R) promotes cancer cell growth (40) and M2 macrophage polarization (41). The gene discussed is IGF1R; the disease is cancer.