In the presence of pre‐invaded macrophages, as confirmed by increased CD14, CD68, and CD11b expression (Figure 1f and Figure S1, Supporting Information), cancer cell invasiveness determined by the number of invaded cells and invasion distance within the ECM significantly increased, suggesting that during invasion into the ECM, macrophages formed a microenvironment favorable for cancer cell invasion (Figure 4b). The gene discussed is CD68; the disease is cancer.