VWA2 and colorectal carcinoma: Currently, postoperative monitoring of serum CEA for early detection of CRC relapse is the standard of clinical care25; accordingly, our findings suggest that a two‐marker panel composed of CEA and CCSP‐2 would provide increased sensitivity for early detection of potentially resettable disease recurrence, particularly for CRC cases that show high expression for CCSP‐2 but not for CEA.