Detecting blood biomarkers is a promising noninvasive method for CRC screening.10, 11 Although several blood biomarkers for CRC have been proposed, only a few of them are available for clinical use.12, 13, 14, 15, 16, 17 Among the candidate biomarkers, colon cancer secreted protein‐2 (CCSP‐2) is a potentially promising blood biomarker.18 CCSP‐2 mRNA expression was shown to be markedly upregulated in CRCs, with colon cancer tumors showing a mean of 78‐fold higher expression compared with matched normal mucosa. The gene discussed is VWA2; the disease is malignant colon neoplasm.