VEGFA and cancer: On the other hand, in vitro studies showed that antiangiogenic effects rely on some shared ability to downregulate, in the same cancer cells, VEGF, TNF-α, and HIF-1α messengers and/or proteins levels (with mechanisms ranging from low expression and higher degradation), blocking the angiogenic cascade in endothelial cells, as shown for berberine [102, 106], noscapine [97], brucine [140], evodiamine [146], homoharringtonine [149], matrine [162], and tetrandrine [136].