Several studies have reported an imbalance between elevated levels of proinflammatory cytokines, such as IL-1, IL-6, IL-8, IL-12, tumor necrosis factor-alpha (TNF-α), and decreased level of anti-inflammatory cytokines, such as transforming growth factor-beta and IL-10 in patients suffering from depression [70, 71]. The gene discussed is TNF; the disease is major depressive disorder.