Heidenreich et al. revealed a large spectrum of proangiogenic factors to mediate in psoriasis, including VEGF, HIF-1α, TNF, angiopoietins, IL-8, IL-17, and TGF-α [78].VEGF expression, in particular, remarkably elevated in the psoriatic serum and lesions. This evidence concerns the gene HIF1A and psoriasis.