TGFB1 and Hepatic fibrosis: Previous studies demonstrated that modulation of HSP90 affects TGF-β-induced collagen synthesis in dermal fibroblasts, [15], attenuates renal fibrosis through degradation of the TGF-β type II receptor in TGF-β1-treated renal tubular cells and in a murine CKD model [44], regulates the fibroblast activation in pulmonary and hepatic fibrosis [16, 45], and hampers the inflammatory response in atherosclerosis [46] and in ischemia-reperfusion injury in the kidney [47].