A cut-off value of I-FABP for NEC was determined to be 9 ng/ml in plasma and 218 ng/ml in urine 0-8 h after the onset of symptoms, and that for severe NEC was 19 ng/ml in plasma and 232 ng/ml in urine 8-16 h after the onset of symptoms [46]. This evidence concerns the gene FABP2 and necrotizing enterocolitis.