COMT and Fabry disease: Genes that play important roles in the regulation of enteric primary afferents and brain-gut interaction (5-HT receptor genes, TRPV1, COMT, and SCN10), induction of inflammatory response (CD14, MIF, TNF-α, IL-17, IL-10, IL-1b, and RANTES), and mediation of gastric accommodation or relaxation (NOS) were hypothesized to be associated to FD susceptibility [24, 30, 65–70].