APOL1 and chronic kidney disease: These analyses identified two genome-wide associated loci: a chromosome 10 locus nearby NMT2 associated with CKD (rs10906850, allele frequency 0.23, p = 3.7 × 10-8) (Table 2 and Figure 2A) and the chromosome 22 APOL1 locus associated with ESKD (four common SNVs, including the two highly correlated APOL1 G1 missense variants rs73885319 and rs60910145) (Figure 2B and Supplementary Table 2).