The APOL1 risk genotypes, including G1, were identified in admixture mapping for ESKD attributed to hypertension, FSGS or HIV (Genovese et al., 2010), and associations have been replicated in population studies although not at the genome-wide significant level (Foster et al., 2013; Kramer et al., 2017). This evidence concerns the gene APOL1 and hypertensive disorder.