The Type I (IFN-I) subfamily consist of all subtypes of IFNα, and IFNβ, IFNκ, IFNω, IFNε, and signal via a receptor consisting of two subunits, interferon-alpha/beta receptor (IFNAR)−1 and IFNAR-2, which are expressed in nearly all cell types and tissues and are known to be paramount for a robust host response against viral infection (16). This evidence concerns the gene IFNA1 and viral infectious disease.