CD4 and systemic lupus erythematosus: miR-126 and miR-148a directly inhibited the expression of DNA methyltransferase 1 (DNMT1), and were overexpressed in SLE CD4+ T-cells, which thus led to DNA hypomethylation, overexpression of CD11a and CD70, and promotion of CD4+ T-cell autoreactivity in SLE (33, 34).