MUC5AC and obesity due to melanocortin 4 receptor deficiency: In this context, the 78 upregulated extracellular proteins in mucin (-) conditions compared to mucin (+) conditions (fold change > 2, Padj < 0.01), similar to Amuc_1100, can be thought of as potential candidate proteins for beneficial effects of A. muciniphila in HFD-induced obesity, but additional confirmation is required.