Various mouse models have illustrated the role of TLR4 in pregnancy associated infections and disorders, including malaria (Barboza et al., 2017; Rodrigues-Duarte et al., 2018), bacterial infections (Liu et al., 2007; Arce et al., 2012; Chin et al., 2016), lipopolysaccharide exposure (Breen et al., 2012; Wahid et al., 2015) and uterine ischemia (Thaete et al., 2013). This evidence concerns the gene TLR4 and malaria.