TLR4 and malaria: In mice, TLR4 has been implicated in dendritic and mast cell activation during malaria (Furuta et al., 2008; Seixas et al., 2009), potentially contributing to the resistance of DBA/2 mice to infection with P. yoelii, although TLR4 has not been linked to the pathology of experimental cerebral malaria (Togbe et al., 2007).