TLR4 and preeclampsia: It has been observed that fetoplacental TLR4 expression is decreased in miscarriages (Kolben et al., 2019) and in preeclampsia patients (Kulikova et al., 2016), while the Tlr4 Asp299Gly polymorphism in the fetus is associated with severe prematurity (Rey et al., 2008).