KISS1R and Infertility: However, the POA nNOS neurons, unlike GnRH neurons, appear not to be the key site of KP-GPR54 signaling for fertility, since GnRH neuron-specific deletion of GPR54 prevents gonadal/pubertal development and results in infertility while GnRH neuron-specific rescue of GPR54 in global GPR54 knockout mice results in normal pubertal development and fertility (3).