In an recent study on 51 adult patients with hypogonadotropic hypogonadism who had undergone one treatment cycle with FSH (urinary or recombinant FSH) plus hCG, those patients who had hypogonadotropic hypogonadism acquired after puberty or had a pubertal arrest showed significantly better treatment outcome (15). This evidence concerns the gene BRD2 and hypogonadotropic hypogonadism.