Several other trials like the PEARL, NeoPalAna, neoMONARCH, FELINE, CORALLEEN, PELOPS, KENDO (ClinicalTrials.gov Identifier: NCT03227328), and SONIA (ClinicalTrials.gov Identifier: NCT03425838) trials, all are focused toward evaluating the efficacy of CDK4/6 in the advanced ER+ BC and in other BC subtypes (245). This evidence concerns the gene ESR1 and breast cancer.