CYP3A4 and breast cancer: In a separate study, it was noted that upregulation of the CYP3A4 enzyme played a crucial role in tamoxifen resistant BC cells and this was attributed partially to the 11,12-epoxyeicosatrienoic (11-12-EET) acid pathway and thus drugs targeting the CYP3A4/11,12-EET pathway may serve as suitable therapeutic drugs (413).