MAPT and Cognitive impairment: The APA test has been shown to detect cognitive deficits following single and rCBI in mice at a more acute time period (12) and for up to 12 months following repetitive mild TBI in a human tau-expressing transgenic mouse model (62); it is a particularly difficult task as it requires the animal to attend only to stationary visual room cues, ignoring the olfactory cues on the rotating apparatus and to continue to move with the arena in order to avoid the shock zone (63).