HTR1B and migraine disorder: Peroutka et al. demonstrated that migraine drugs, including ergotamine, dihydroergotamine, and sumatriptan, show affinity for the 5-HT1A, 5-HT1B, and 5-HT1D receptors, suggesting that these 5-HT receptors are involved in the action of the these antimigraine drugs (82, 83).