Furthermore, treatment with 5-HT1A agonist/5-HT3 antagonist could inhibit the Bezold–Jarisch reflex and stress-induced defecation in this rat model; thus, agents that exert effects via 5-HT1A agonistic and/or 5-HT3 antagonistic activities might be beneficial for IBS treatment (36, 37). The gene discussed is HTR1A; the disease is irritable bowel syndrome.