We further divided the five components of metabolic syndrome (abdominal obesity, high Fasting blood glucose, high blood pressure, increased triglyceride, and decrease in HDL cholesterol concentration) and in most cases the accumulation of these components associated with a higher level of sTNFRII, sICAM-1 and TIMP-1 (Table 3). The gene discussed is TIMP1; the disease is Abdominal obesity.