AKT1 and cancer: Proliferation and apoptosis of cancers are regulated by multi-signaling pathways, such as PI3K/AKT/mTOR, MAPK/ERK, and STAT3 (Daniel and Mcleod, 2005; Mei et al., 2007; Gao and Tian, 2010; Guo et al., 2015; Cheng et al., 2017).