However, in spite of the investigations demonstrating efficacy and safety in the use of linagliptin associated with insulin, in none of them was justified the rationale of this association, since the progression of DM2 reflects in the reduction of the production of insulin by the organism, a consequence of the reduction of the functioning beta cells (International Diabetes Federation [IDF], 2017). Here, INS is linked to myotonic dystrophy type 2.