KATP channels couple the metabolic state of the cell to membrane excitability and play a key role in physiological processes such as insulin secretion in the pancreas (Ashcroft, 2005), protection of cardiac muscle during ischemia (Nichols and Lederer, 1991; Crawford et al., 2002; Zingman et al., 2007), and hypoxic vasodilation of arterial smooth muscle cells (Dart and Standen, 1995). Here, INS is linked to ischemia.