A reasonable conjecture is concluded that lncRNA CRNG could participate in several viral reproductions, responding to virus, infection and immune-inflammation through regulating the genes expression of inflammation and antiviral immunity, including ANPEP, KITLG, STAT5A, FOXP3, miR-451 and immune and inflammatory factors, IL-2, IL-10, IL-6, TNF-α (Figure 8). The gene discussed is TNF; the disease is infection.