Present study showed that lncRNA CRNG predominantly associated with viral reproduction, response to virus, pathogen infection and the immune-inflammatory responses through regulating the genes of inflammation, pathogen infection and antiviral immunity, such as ANPEP, KITLG, STAT5A, FOXP3, miR-451 and immune and inflammatory factors, such as IL-2, IL-10, IL-6, TNF-α. The gene discussed is IL10; the disease is infection.