ACEIs and AT1R blockers, have already showed significant efficacy in the treatment of heart failure by reducing cardiac fibrosis in human and in animal models (Varo et al., 1999; Brilla et al., 2000; Ciulla et al., 2004; Tyralla et al., 2011; Muller et al., 2013). This evidence concerns the gene AGTR1 and heart failure.