CYP2D6 and breast carcinoma: These data corroborate previous studies demonstrating that doses escalation of tamoxifen in CYP2D6 compromised breast cancer patients is well tolerated (Barginear et al., 2011; Irvin et al., 2011; Kiyotani et al., 2012; Dezentjé et al., 2015; Fox et al., 2016; Hertz et al., 2016).