In addition, TP can promote apoptosis and suppress cell proliferation in hepatocellular carcinoma, potentially via inhibition of miR-17-92 and miR-106b-25, in a c-MYC-dependent manner, leading to an increase of BIM, PTEN, and P21 levels (Li S. G. et al., 2018). Here, CDKN1A is linked to hepatocellular carcinoma.