It can modulate the expression of kelch-like ECH-associated protein-1 (Keap1), a hepatic carcinoma factor, by interacting with Nrf2 binding site and restraining it from binding to Keap1 and elevating the expressions of vital antioxidative signals like HO-1 (Yang et al., 2017). Here, KEAP1 is linked to hepatocellular carcinoma.