It compactly gives an overview of genes of interest, representative gene subsets that were involved in regulated signaling pathways, including tumor necrosis factor (TNF), P53, NF-κB, chemokine, peroxisome proliferator activated receptor (PPAR) and Toll-like receptor (TLR) signaling pathways associated with the physiology of various hepatic disease. The gene discussed is TNF; the disease is liver disorder.