The impact of PCSK9 on neurocognitive performances in pre-clinical models has been indirectly suggested by the observation that deletion of the LRP1, which is sensitive to the degrading action of PCSK9 (Canuel et al., 2013), leads to a reduced Aβ clearance and to cognitive deficits in mice (Storck et al., 2016). Here, PCSK9 is linked to Cognitive impairment.