PCSK9 and Alzheimer disease: Although Wollmer (2010) first identified PCSK9 among the cholesterol-related genes that have been matched with AD genes listed in the AlzGene database, no association was found between PCSK9 polymorphism and the risk of AD onset, neither in a Japanese nor in a Swedish cohort study (Shibata et al., 2005; Reynolds et al., 2010).