Modules associated with AD were the red and pink modules, which are mainly enriched in microglia, monocytes, and macrophages, mediating the down-regulation of the ribosome, peptide biosynthetic process, and leukocyte transendothelial migration, as well as the up-regulation of cytokine secretion, NOD-like receptor signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, and positive regulation of oxidative stress-induced neuron death. This evidence concerns the gene TNF and Alzheimer disease.