INS and Alzheimer disease: Modules associated with all stages of AD were the blue and brown modules, which are mainly enriched in monocytes and macrophages, mediating the down-regulation of translation, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, oxidative phosphorylation, and ribosome, as well as the up-regulation of leukocyte activation, vesicle-mediated transport, insulin resistance, lysosome, autophagy and endocytosis, etc. It is worth noting that the ME expression level of blue was up-regulated mainly in the MCI stage.