To clarify some of the issues discussed in the previous paragraph, we investigated: (i) whether changes in brain regions linked to hypoglycemia, such as the DMN, are modulated by insulin and glucose or different metabolic states; and (ii) whether changes in activity of specific brain regions, such as hypothalamus and insula, are modulated by changes of blood insulin or glucose levels after glucose administration. This evidence concerns the gene INS and Hypoglycemia.