Immunohistochemical techniques and subsequent use of anti-α-synuclein antibodies (Spillantini et al., 1997) further revealed that the primary component of Lewy bodies is α-synuclein (α-syn) in DLB (Spillantini et al., 1998; Beyer et al., 2009; Kim et al., 2014). This evidence concerns the gene SNCA and Lewy body dementia.