AKT1 and coronary artery disorder: Together with other evidence, such as the mediation of statin protection by the phosphorylated Akt, GSK-3β (inhibition), and CREB and the functions of OT at other tissues (Klein et al., 2014; Watanabe et al., 2016), we propose the presence of an OTR signaling network that protects the CVS from atherosclerotic injury and CAD (Figure 2).