Together with other evidence, such as the mediation of statin protection by the phosphorylated Akt, GSK-3β (inhibition), and CREB and the functions of OT at other tissues (Klein et al., 2014; Watanabe et al., 2016), we propose the presence of an OTR signaling network that protects the CVS from atherosclerotic injury and CAD (Figure 2). Here, OXTR is linked to coronary artery disorder.